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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TLK2 All Species: 19.09
Human Site: S115 Identified Species: 42
UniProt: Q86UE8 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86UE8 NP_001106178.1 772 87661 S115 A R S S P Q H S L S N P L P R
Chimpanzee Pan troglodytes XP_523598 848 95816 S213 A R S S P Q H S L S N P L P R
Rhesus Macaque Macaca mulatta XP_001107302 907 100501 S253 A R S S P Q H S L S N P L P R
Dog Lupus familis XP_548038 918 102784 S283 A R S S P Q H S L S N P L P R
Cat Felis silvestris
Mouse Mus musculus O55047 718 82242 A113 E A S E E Q S A L P T L M S V
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515053 718 81881 Q124 P P A I R S P Q N S H S H S T
Chicken Gallus gallus XP_418070 750 85456 S115 A R S S P Q H S L S N P L P R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q1ECX4 697 79286 P111 P P V A R S S P Q H S L S N P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624065 793 90042 M154 S P Q Q G Y P M Y P P S P Q Q
Nematode Worm Caenorhab. elegans P34314 965 109255 T261 G G T P Q R P T A P Q S S T A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q39238 688 78131 Q102 T K K R Q K V Q E S N N F S V
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88.3 82.3 81.2 N.A. 92.4 N.A. N.A. 68.6 94.1 N.A. 77.9 N.A. N.A. 47.9 36.5 N.A.
Protein Similarity: 100 88.3 83 81.3 N.A. 92.7 N.A. N.A. 77.7 95.8 N.A. 83.9 N.A. N.A. 63.4 50.1 N.A.
P-Site Identity: 100 100 100 100 N.A. 20 N.A. N.A. 6.6 100 N.A. 0 N.A. N.A. 0 0 N.A.
P-Site Similarity: 100 100 100 100 N.A. 33.3 N.A. N.A. 20 100 N.A. 13.3 N.A. N.A. 13.3 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 35.3 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 50.2 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 46 10 10 10 0 0 0 10 10 0 0 0 0 0 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 10 0 0 10 10 0 0 0 10 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % F
% Gly: 10 10 0 0 10 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 46 0 0 10 10 0 10 0 0 % H
% Ile: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 10 10 0 0 10 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 55 0 0 19 46 0 0 % L
% Met: 0 0 0 0 0 0 0 10 0 0 0 0 10 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 10 0 55 10 0 10 0 % N
% Pro: 19 28 0 10 46 0 28 10 0 28 10 46 10 46 10 % P
% Gln: 0 0 10 10 19 55 0 19 10 0 10 0 0 10 10 % Q
% Arg: 0 46 0 10 19 10 0 0 0 0 0 0 0 0 46 % R
% Ser: 10 0 55 46 0 19 19 46 0 64 10 28 19 28 0 % S
% Thr: 10 0 10 0 0 0 0 10 0 0 10 0 0 10 10 % T
% Val: 0 0 10 0 0 0 10 0 0 0 0 0 0 0 19 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 10 0 0 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _